Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease
نویسندگان
چکیده
منابع مشابه
Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease.
AIMS Myxomatous valve disease (MVD) is the most common aetiology of primary mitral regurgitation. Recent studies suggest that defects in heart valve development can lead to heart valve disease in adults. Wnt/β-catenin signalling is active during heart valve development and has been reported in human MVD. The consequences of increased Wnt/β-catenin signalling due to Axin2 deficiency in postnatal...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2016
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvw229